Consulta: subjectFacets:"CYP1A1"
Registros recuperados: 8
Data/hora: 18/05/2024 17:20:06

CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
Provedor de dados: Genetics and Molecular Biology
Autores: Coura,Renata dos Santos; Marques,Christiane de Fátima Silva; Koifman,Rosalina J.; Koifman,Sergio; Cabello,Pedro Hernan; Hatagima,Ana.
The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytochromes P450; CYP1A1; CYP2E1; Brazil.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001

CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Leichsenring,A.; Losi-Guembarovski,R.; Maciel,M.E.; Losi-Guembarovski,A.; Oliveira,B.W.; Ramos,G.; Cavalcanti,T.C.S.; Bicalho,M.G.; Cavalli,I.J.; Cólus,I.M.S.; Ribeiro,E.M.S.F.
CYP1A1 and GSTP1 polymorphisms have been associated with a higher risk to develop several cancers, including oral squamous cell carcinoma (OSCC), which is closely related to tobacco and alcohol consumption. Both genes code for enzymes that have an important role in activating or detoxifying carcinogenic elements found in tobacco and other compounds, and polymorphic variants of these genes may result in alterations of the enzymatic activity. The CYP1A1 gene codes for the enzyme aryl hydrocarbon hydroxylase, which is responsible for the metabolism of polycyclic aromatic hydrocarbons. The investigated polymorphism, Ile/Val, seems to increase the activity of the enzyme in homozygous individuals, leading to an accumulation of carcinogens. The Ile/Val...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oral carcinoma; Biometabolism genes; CYP1A1; GSTP1; Gene polymorphism.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200007

CYP1A1, CYP2E1 Y RIESGO A CÁNCER GÁSTRICO EN UNA POBLACIÓN COLOMBIANA DE ALTA INCIDENCIA
Provedor de dados: Acta Biológica Colombiana
Autores: Castaño-Molina,Eduardo; Santacoloma,Mario; Arango,Lázaro; Camargo,Mauricio.
El objetivo fue probar la hipótesis de que en casos y controles, de una población colombiana con alta incidencia de cáncer gástrico, muestran diferencias significativas entre las frecuencias de los polimorfismos genéticos CYP1A1*2A y CYP2E1*5A; y a la vez, probar si hay diferencias entre el hábito del tabaquismo, el consumo de alcohol y el estrato socioeconómico; así como también sus posibles interacciones. Durante dos años consecutivos se diagnosticaron y confirmaron ochenta y siete casos nuevos de pacientes afectados por cáncer gástrico y se colectaron igual número de controles pareados por edad y del mismo grupo poblacional, pertenecientes a la comunidad “paisa” del departamento de Caldas. Se genotipificaron por medio de PCR-RFLPs para los polimorfismos...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CYP1A1; CYP2E1; Colombia; Cáncer gástrico; Tabaquismo; Estrato socioeconómico.
Ano: 2009
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2009000300016

CYP1A1 genotypes and haplotypes and risk of oral cancer: a case-control study in South Indians
Provedor de dados: Genetics and Molecular Biology
Autores: Balaji,Lakshmi; Singh,Krishna Balaji; Bhaskar,Lakkakula V.K.S.
The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G &gt; A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G &gt; A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CYP1A1; Haplotypes; Allele; Oral cancer.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300004

CYP1A1, GSTM1, GSTT1 and GSTP1 polymorphisms in an Afro-Brazilian group
Provedor de dados: Genetics and Molecular Biology
Autores: Kvitko,Kátia; Gaspar,Pedro de Abreu; Torres,Martiela Ribeiro; Hutz,Mara H.
Gene polymorphisms involved in the metabolism of drugs and chemical carcinogens seem to be responsible for differences in the susceptibility of individuals to cancer, but genetic population studies are needed to characterize these polymorphisms in different ethnic populations. We investigated polymorphisms of the cytochrome P450 (CYP) gene CYP1A1 and the glutathione S-transferase (GSTs) genes GSTM1, GSTT1 and GSTP1 in a sample of Afro-Brazilians from the southern Brazilian city of Porto Alegre to verify if there were ethnic differences compared to the polymorphisms of the same genes in a previously described sample of Brazilians of European descent from the same city. The allele frequencies detected in the Afro-Brazilian population investigated in this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: African; Brazilian; CYP1A1; European; GSTs; Porto Alegre.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000400006

Mutational analysis of xenobiotic metabolizing genes (CYP1A1 and GSTP1) in sporadic head and neck cancer patients
Provedor de dados: Genetics and Molecular Biology
Autores: Masood,Nosheen; Kayani,Mahmood Akhtar.
CYP1A1 is the phase I enzyme that detoxifies the carcinogen or converts it into a more electrophilic form, metabolized by phase II enzymes like GSTP1. These detoxifying genes have been extensively studied in association with head and neck cancer (HNC) in different ethnic groups worldwide. The current study was aimed at screening genetic polymorphisms of genes CYP1A1 and GSTP1 in 388 Pakistani HNC patients and 150 cancer-free healthy controls, using PCR-SSCP. No already known variants of either gene were found, however a novel frameshift mutation due to insertion of T (g.2842_2843insT) was observed in the CYP1A1 gene. A statistically significant number (5.4%) of HNC cases, with the mean age of 51.75 (±15.7) years, presented this frameshift mutation in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: GSTP1; CYP1A1; Head and neck cancer; Polymorphisms; Mutations.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400001

Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)
Provedor de dados: Genetics and Molecular Biology
Autores: Santovito,Alfredo; Burgarello,Claudio; Cervella,Piero; Delpero,Massimiliano.
In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast. As appeared in several published studies, ethnic differences in these frequencies have been found to play an important role in the metabolism of a relevant number of human carcinogens. In the studied sample, the frequencies of Ile/Ile (wild type), Ile/Val (heterozygous variant), and Val/Val (homozygous variant) CYP1A1 genotypes were 0.271, 0.692, and 0.037, respectively. Frequencies of GSTM1 and GSTT1 null genotypes were 0.361 and 0.331, respectively. No significant differences were noted between men and women. In contrast to published data for Africans,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CYP1A1; GSTM1; GSTT1; Genetic polymorphism; Ouangolodougou.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300006

Recherche des marqueurs d'exposition aux contaminants et de fréquentation des habitats chez l'anguille Anguilla anguilla de l'estuaire de l'Adour : de la réponse moléculaire à la microchimie de l'otolithe
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Tabouret, Helene.
In a context of decline of European eel (Anguilla anguilla L.) and search for biological markers of habitat use and quality, a multidisciplinary approach was engaged on the Adour estuary and its associated wetlands. Two axes were developed. The first axe aimed at highlighting the successive presence of the species in different ecosystems based on the otolith elemental composition. The second aimed at the evaluation of the chemical pressure underwent by eels based on the contaminant bioconcentration in soft tissues and the early molecular response to the chemical stress. With a view to the analyses of otolith elemental composition taking into account the 3D structure, the low elemental concentration in the matrix and keeping the finest spatial resolution,...
Tipo: Text
Palavras-chave: Adour; Polychlorinated biphenyls; Mercury; CYP1A1; Fs LA ICP MS; Microchemistry; Otolith; Anguilla anguilla; Adour; Polychlorobiphényles; Mercure; CYP1A1; Fs LA ICP MS; Microchimie; Otolithe; Anguilla anguilla.
Ano: 2009
URL: http://archimer.ifremer.fr/doc/2009/these-7381.pdf